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AURX is some sort of herpes cure
that people have debated on the internet for years! AURX is said to be a
way people can try to treat herpes. If you have tried AURX please share
your positive or negative experiences for posting on this feedback page.
Send me your comments and feedback along with your blessing to post on
the site. All names and e-mail addresses will be kept confidential.
AURX - Have you tried it?
I have recently found out that the AURX company has
a deadline of September 20, 2004 to receive sufficient funding. Without more
investors they will not be able to continue their clinical trials and their new
treatment will never be able to be approved by the FDA. They need
qualified investors that would be willing to invest at least 100,000 dollars.
If you know of anyone that might be interested please have them
contact AURX before it is too late. I hope that with
your help more investors will be found and this new treatment might be
available one day. - Jacquelyn
We all have
come to Yosh's
the same reason, in one way or another HSV has touched our lives. We may
only be afraid that we have it, a loved one might have it or we may have it
ourselves. Regardless of the reasons for our interest in bettering our
knowledge on the virus, it is obvious that it has a wide-spread effect on
people it has effected, in one way or another. To put it simply, for the
vast majority of people, the long-terms health problems involved with HSV2
are no more than an inconvenience.
There are those unfortunate few who
suffer long-term, painful occurrences, their suffering and plight should not
be downplayed or forgotten. But the vast majority of those looking for HSV
relief arenít looking for alleviation of physical symptoms, they are looking
for relief from the psychological burden associated with the stigma of
having this virus, people simply want their lives back. It is a sad
statement, but nevertheless accurate, that no amount of public education
will totally change the perception held by the vast majority of people
regarding HSV2, the only thing that will is a cure.
Lets face it, if 90% of
people with genital herpes donít even realize that they have it, then what
we are dealing with, for all intents and purposes, is something that is so
minor physically that it isnít even given a second thought! Even in its
worst form, painful lesions, if people knew that guaranteed and sustained
relief was only an injection away, HSV2 would only be seen as little more
than an embarrassment soon forgotten, much like having to deal with an early
outbreak of chlamydia - a couple of shots and you are rid of it. No
sleepless nights, no painful, embarrassing talks with a loved one - just
peace of mind and hopefully lesson learned!
So this brings
us to the topic of a "herpes cure." I would guess that a cure for different people
would involve different things: some would only want relief from symptoms,
some would only hope to prevent transmission to others or to suppress the
virus inside of them, others would want the virus totally eliminated from
their body forever - again, it depends on who you ask, they each have their
For myself the only pain I derive from this virus is the
emotional and psychological aspect of having it. My outbreaks are barely
noticeable, cause me no real physical pain for that I am truly thankful.
Yet, despite having no physical symptoms worth mentioning, I'm left with
this huge burden to have to deal with. As of now, Iím 21 years old, just
starting my life free of school and youthful trappings. I was looking
forward to soon starting a family of my own and moving on with my life. It's
funny how all of these plans of mine have suddenly been given a new twist,
not that they are impossible but in this day and age HSV2 makes my life much
more difficult than I want it to be!
I have only been dealt this hand for a
few months now, since that date I have searched high and low for
information, research and future prospects. As we all no there is no
definitive cure and nothing that will take this virus from the ganglia and out
of our bodies forever. However there are several companies making strides
to develop treatments that will contain the virus inside us, not allowing it
to travel to the skin's surface. In essence, I think that this is just as
good as a cure!
Lets put this
into perspective, if those of us with HSV2 were not contagious, would we
worry about it? I for one can honestly say no - if I had to tell a new
girlfriend that yes, I do have HSV2, BUT she was at no risk of catching it,
then would she care? If she truly liked me then I would hope not! There
are those who will argue that if she is really worth it, then she will look
beyond the risks to herself, because HSV2 doesnít make us who we are. While
this may be true, I know that I could never blame someone, especially at my
age, for not being willing to take the risk involved only because I know
the enormous effect that this virus yields! HSV2 is a HUGE first hurdle to
have to get over in any relationship!
This brings us back to the R&D going
on, which is the main reason behind this open letter. As I stated before,
there are a couple of companies taking different approaches to suppressing
HSV2, unfortunately most are in early development and relief, even if these
treatments prove to be successful, is years away.
However, there is one company
(with which I am not affiliated with in ANY way) that is a little further
along the way when it comes to getting their product into the hands of
people who want it so badly. The name of the company is AURX (AURX.com)
For several years the company has been testing a herpes vaccine developed by Dr.
Laura Aurelian and Dr Cynthia Smith, both professors at the University of
Maryland. (pharmacology.umaryland.edu/laurelian/) To date, in spite
of negativity towards their theories (which thus far has been proven to be
unjustified), the AURX vaccine has been proven effective in HSV2 treatment
on a scale not seen before. It has passed animal, pre-clinical and Phase 1
and 2 clinical trials in humans, all with excellent results. For those
unfamiliar with what is involved with approving a new drug, Phase 3 success
is all that stands in the way of AURX and final review (and hopefully
approval) from the FDA. I myself am no scientist or biology expert, I can't
claim to understand what it means when "ICP10 PK"
or "anti-apoptotic activity."
However, what I can understand is the results that they have gathered so
far, clinically: in the Phase 2 study, over 80% were lesion free for one
year, over 35% were completely symptom free (not only lesion, but itching,
tingling, etc.), all of this achieved with an un-optimized dose of the AURX
vaccine. That in itself is enough to put this vaccine far ahead of current
treatments in terms of relief, but AURX is hoping not to stop there.
what I understand, a major part of Phase 3 trials will involve testing for
asymptomatic shedding, to see if the vaccine not only brings relief to
visible symptoms, but also prevents the most dangerous aspect of this
virus. Again, the dosage has not been optimized...who knows what the
results would be once it is - there is only one way to find out! This is
where the company is running into problems however, funding for this
project, for one reason or another, is proving to be a problem.
Conspiracy theories as to why this is the
case is a topic for another
the bottom line is that this research MUST continue, not so much for the
success of AURX, but for the cause of HSV2 sufferers. I will be the first
to admit that there are no guarantees regarding the success of this vaccine,
it may go the way of other potential treatments which failed in Phase 3, but
I hold out hope that it at least gets a chance to prove itself. It would be
one thing if the vaccine attempted and failed, but to never have the
opportunity to continue, regardless of the outcome, would be a horrible
shame. At the very least, by proceeding with the next phase, we will learn
what needs to be improved on. I hold out great optimism for the success of
AURX, this is the life's work of Dr. Aurelian, all involved are credible and
knowledgeable scientists and thus far, the results speak for themselves!
To put into words what I would see as the
best-case scenario for a happy AURX ending: the product passes all
requirements and proves itself to be effective. Those with HSV2 pay to get
their shot (even if it is once a year) and HSV is nothing more than an
embarrassing memory! Imagine being rid of HSV2 and all that goes with it
with the same ease that you received booster shots as a child! At the very
LEAST, in a worst case scenario, AURX doesn't live up to expectations, then
the next researcher that comes along can look at these shortcomings and
improve on them. I donít care if someone stands on the "shoulders of
giants" as long as they can help me get my life back!
with AURX know that they were trying to compile a list of names interested
in participating in clinical trials, as a tactic to prove to investors that
there is interest in their product. It seems that they have succeeded in
this registry to a certain degree, as I received an email in response to an
inquiry that I made regarding the status of the company: "We are seeking funding.
Time is now
very short. If you know of qualified investors who might be
interested in the current effort to secure funding, please have them contact
us." While this provides a glimmer of hope that
someone will come through for AURX, that glimmer is fading. I donít know if
there are any investors reading this post, but I hope that those who do read
it, regardless of their financial status, will show support for AURX's work,
whether it be by email, telephone call or letter, this will show that this
treatment is still desired, no matter where it comes from! If, by chance,
there are investors reading this right now, Iím not saying invest in AURX
based on my word alone. Do your research into their clinical findings, also
realize the enormous potential this product has for generating revenue.
If things continue to go
well, in a couple of years, the herpes preventing vaccine Herpevac will be
out on the market. I know my daughter will be in line to get her shots (if
I have one in the future) and hopefully, within a couple of generations, HSV
will be a distant memory. The approach of containment to eliminate the
virus is a commendable one and probably the most realistic. But at the same
time, I donít want to be a part of the "forgotten generation", who had the
misfortune of contracting HSV2 at the time when the focus switched from cure
to prevention. I donít want to be forgotten only because the light at the
end of the HSV tunnel is only a couple of generations away! Give AURX a
chance to prove itself, thatís all I ask. Because, whether they succeed or
fail, it will bring us closer to finding that "silver bullet" for this
virus. Research must continue into the suppression of this virus in people
who already have it, Phase 3 for AURX is a step in the right direction.
What happens next is out of my hands; it is up to the people with more means
than I have. For those who are able to invest, I urge you to do so. For
those who can't, I hope you take a few minutes to at least show your support
to AURX, find out whatís going on - call, email etc, show them that people
are interested and care. For those who have lived many years with this
virus, who were lucky enough to start families and live relatively normal
lives, please donít forget what it was like to be 20 something with HSV and
uncertain about your future, although HSV may be a small part of your life
now, please donít forget the rest of us just starting out, help us in this
small way. For those like me, who are just starting out, take the
initiative; donít wait for others to lead the way, because you will be
waiting the rest of your lives if you do. We have to turn around this
defeatist attitude that HSV+ people seem to have, in terms of beating this
virus. To state that we all want to be cured goes without saying, but it is
time to state the obvious to the companies and those who make the financial
decisions, if we let AURX, with all of its potential, go down without a
fight, then what are we waiting to fight for when it comes to this virus? -
cure we may never see - on 7/27/2004 10:06:41 AM,
I discussed this vaccine with Anna Wald and with
Lawrence Stanberry, both people with great expertise in herpes vaccine
trials. Both felt that there were significant problems with the research
methodology with the AURX trials and thus, with the data.
Having been in this business for over 22 years, I've seen big drug
companies snap up little companies or their products when they believe
that there is a potentially successful treatment to be obtained. I
obviously have no idea if overtures have been made to this company, but
I would say that I personally haven't heard of any. That may be worth
something or absolutely nothing.
I certainly would discourage no one from signing up for their trials,
however. The more possibilities that we have for success with herpes,
the better, in my book.
It is important to note that there are ongoing and upcoming clinical
trials, in the US (AURX was done in Mexico, I believe) of a therapeutic
vaccine by a company called Antigenics. You can also find out more
information about that trial on their website. We are one of five sites
that will be conducting their trials in the fall (we hope the fall). I
also personally offered AURX our clinic as a site for doing their trial,
at what I hoped would be a very reasonable cost, but did not hear more
from them about my offer. I'm not sure exactly what's going on with
them, but as I said earlier, the more options we have for research, the
better! I hope that they succeed in getting enough folks for their next
phase trial, that it happens in the US, and that the methodology is up
to the very stringent criteria set by our nationally respected herpes
researchers. That is important so that the FDA will see the results are
being worthy of awarding approval.
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