I hear this is some pretty scary stuff to mess with...
Angela



Jason wrote:Just google "DMSO safe?" for more on this. The big pharma doesn't want you using ANYTHING they can't make a dollar on. Most of the people in the FDA were former big Pharma researchers etc. See the problem?
Timf wrote:Jason wrote:Just google "DMSO safe?" for more on this. The big pharma doesn't want you using ANYTHING they can't make a dollar on. Most of the people in the FDA were former big Pharma researchers etc. See the problem?
The problem with this reasoning is that it is flawed in this case. DMSO is prepped for pharmaceutical use as a solvent, for human and animal clinical use by who - pharmaceutical companies - so they can or rather they do already happily make a lot of bucks on it. A bottle of 500ml of the stuff that meets USP regs costs 82 GBP without sales taxes/VAT (about 160USD) from one major lab chemical supplier here in the UK. Plenty of profit in there because they are already making it - any scaling up improves the profit.
Moving onto the two main aspects people are asking here - 1) safety and 2) efficacy vs Herpes - with respect to herpes Ive used it as a carrier for drugs in antiviral experiments on HSV1 and 2, EHV, and BHV. I never saw any knockdown from experiments using the carrier (ie DMSO) alone - that was one of the reasons we used it. It has been clinically used in the UK as a carrier for an anti-herpetic drug (idoxuridine) for zoster and if it had had a big effect alone it would have been picked up there as there is a large body of work done on it. DMSO alone generally comes up negative overall from al the data Ive seen. You can certainly find it helping other drugs, Berman and Hamuy see it help interferon studies for instance.
The stuff is used a HUGE amount in biomed research as well as its use in clinical practise. There was a LOT of work done on DMSO and its safety and most of it comes from the 60s, 70s and the 80s and you can find a HUGE amount of papers using it in Pubmed - including a lot on the worries people had about it and how much of those worries are justified (Jacob is one of the big authors in the field in the 60s and 70s). There is simply too much work with the compound to go through what effects it has been seen to have and have not been seen. Last time I went through this I spent 2 weeks scanning the data and you can find all sorts of commentary positive and negative. Despite the time since the work was done the two review papers that most work keeps coming back to are;
Brobyn (1975) Ann N Y Aca Sci, vol243 pp497-506 for toxicity and
Swanson (1985) Rev Clin Basic Pharm vol 5 p1-33 for medical use of the stuff.
I did have self contained document on the stuff as well but I appear to have misplaced it.
The compound has some issues - so do many - but it is used, the more you use and more internal the use gets the more careful you have to be and there have been some reports of significant side effects in humans - but it is used clinically. Its not a dripping deadly poison, but its not innocuous and has some serious issues to really think about before touching it (hence why its use tends to come under the supervision of a professional).
We handle it very carefully in the lab for 2 main reasons - 1) at a cosmetic level it stinks to high heaven and you end up tasting it and 2) anything it comes into contact with tends to get picked up and carried elsewhere where you don't want it. The single biggest worry is what else other than itself it take over the skin barrier and what someone else has managed to contaminate your bottle with.
So, no I dont handle it like its hydrogen cyanide, however nor do I throw it around like its sodium chloride. However, I treat it with care and awareness of both its own properties and how it affects and is affected by other things for a reason. Its not always simply an issue of what the DMSO is doing, but what it may allow to have an effect - and thats a BIG problem potentially so it is something to think about.
maxmoreno wrote:Hello,
I have reviewed the information for DMSO on http://www.dmso-use.com
and I was wondering if somebody has experienced this
medicine. Can we consider this as a common way of healing?
Thank you.[/url]
This is some excellent information Tim thank you.
I am trying to find out who may own the patent on DMSO if there is one. It was discovered so long ago there may not be one right?
I still have to state with the utmost confidence that applying a relatively small amount of DMSO to an outbreak - as it's starting - will stop it dead in it's tracks. There is nothing that will change my opinion on this.

Jason wrote:I'm not opposed to prescription medications just opposed to putting blind faith into the FDA. They do not always have our best interests at heart.
So is Avacor better than Valtrex?
I need to get on one of these I feel. No outbreaks but I don't feel comfortable having sex with someone with out being on one of these.



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